反応 #1192

反応方程式

2-ethylhexyl bromide

1,10-decanediol

KOH

→

10-(2-ethylhexyloxy)decanol

収率 72.1%

溶媒

xylene

反応条件

後処理

1. 1
   その他A 1-liter flask equipped with a stirrer
2. 2
   workup.DISTILLATIONdistilling off water
3. 3
   その他formed
4. 4
   温度the resulting mixture was heated
5. 5
   その他After completion of the reaction
6. 6
   洗浄washed with water
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
8. 8
   その他the resulting residue was purified by column chromatography on silica gel

実験手順

A 1-liter flask equipped with a stirrer and distiller was charged with 25 g (0.14 mol) of 1,10-decanediol, 8.09 g (0.14 mol) of KOH and 300 ml of xylene, and the resultant mixture was heated at 120° C. for 1 hour, thereby distilling off water formed. To this reaction mixture, were added 23.1 g (0.12 mol) of 2-ethylhexyl bromide, and the resulting mixture was heated and stirred for 15 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with water. After the solvent was distilled off under reduced pressure, the resulting residue was purified by column chromatography on silica gel, thereby obtaining 24.8 g (yield: 72%) of 10-(2-ethylhexyloxy)decanol.

出典