反応 #11903
ord-058db254e82c45b7899abb07338a96ad
溶媒
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度was gently refluxed for about 16–17 h
- 2その他The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C.
実験手順
A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), methanol (200 ml), and water (1 ml) was gently refluxed for about 16–17 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue.