反応 #11902

反応方程式

trityl candesartan cilexetil

toluene

methanol

→

candesartan cilexetil

溶媒

water

反応条件

後処理

1. 1
   温度was gently refluxed for about 5 h
2. 2
   その他The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. to 60° C.

実験手順

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (120 ml), and water (1 ml) was gently refluxed for about 5 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

出典