反応 #11901

反応方程式

trityl candesartan cilexetil

toluene

methanol

→

candesartan cilexetil

溶媒

water

反応条件

後処理

1. 1
   温度was gently refluxed for about 12 h
2. 2
   その他The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C

実験手順

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (60 ml), and water (1 ml) was gently refluxed for about 12 h. The reaction was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

出典