反応 #1184126

反応方程式

methyl 4-bromobenzoate

2-benzo[b]thiopheneboronic acid

potassium carbonate

→

title compound

Methyl 4-(benzo[b]thiophen-2-yl)benzoate

溶媒

Water

water

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with aqueous saturated sodium chloride solution
3. 3
   乾燥dried with sodium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified through silica gel column chromatography

実験手順

A mixture of methyl 4-bromobenzoate (430 mg, 2.00 mmol), 2-benzo[b]thiopheneboronic acid (392 mg, 2.20 mmol), palladium(0) acetate (2.2 mg, 0.010 mmol), potassium carbonate (691 mg, 5.00 mmol), tetrabutylammonium bromide (645 mg, 2.00 mmol) and water (2.2 mL) was stirred in a nitrogen atmosphere at 70° C. for 1 hour. Water was added to the reaction mixture, and extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography to obtain the title compound as a pale yellow solid.

出典