反応 #1181

反応方程式

4-amino-2-chlorobenzonitrile

SnCl2

NaNO2

→

2-Chloro-4-hydrazinobenzonitrile hydrochloride

溶媒

THF

HCl

HCl

water

反応条件

後処理

1. 1
   workup.WAITthe mixture is left
2. 2
   workup.STIRRINGstirring

実験手順

5 g of 4-amino-2-chlorobenzonitrile and 40 ml of concentrated HCl in 30 ml of THF are mixed at -5° C.; 2.26 g of NaNO2 in 30 ml of water are added and the mixture is left stirring for 2 hours, 30 g of SnCl2 ·2H2O in 30 ml of concentrated HCl are then added and stirring is maintained at -5° C. for 30 minutes.

出典