反応 #1178416

反応方程式

toluene

3-amino-3-methyl-butyric acid

thionyl chloride

→

methyl 3-amino-3-methylbutanoate

溶媒

methanol

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他to give azeotropic

実験手順

To 3-amino-3-methyl-butyric acid 10-1 (1 eq.) in methanol at 0° C. was added 2 eq. of thionyl chloride. The reaction mixture was warmed to room temperature and stirred overnight. The solvent was evaporated to give azeotropic mixture of 10-2 and toluene (x=3) which was used for Step B. MS: MH+=132.1

出典