反応 #1178392

反応方程式

hydrochloric acid

2-hydroxyindane

paraformaldehyde

calcium chloride

→

chloromethyl(2-indanyl)ether

収率 100.3%

溶媒

methylene chloride

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture was agitated for 16 hours
2. 2
   その他After separated an organic layer from the mixture
3. 3
   その他the solvent was removed by distillation

実験手順

A mixture of 134 g of 2-hydroxyindane, 36.1 g of paraformaldehyde, 200 g of calcium chloride, and 1200 g of methylene chloride was agitated. Into the mixture was dropped 239 g of a concentrated hydrochloric acid at room temperature for 3 hours, and then the reaction mixture was agitated for 16 hours. After separated an organic layer from the mixture, the solvent was removed by distillation to obtain 183 g of chloromethyl(2-indanyl)ether as an oily matter.

出典