反応 #11765

反応方程式

(5-chloro-2-methoxy-phenyl)-methanesulfonamide

boron tribromide

→

title compound

収率 86.8%

(5-Chloro-2-hydroxy-phenyl)-methanesulfonamide

収率 86.8%

溶媒

dichloroethane

反応条件

後処理

1. 1
   その他The reaction was quenched with water, saturated with sodium chloride
2. 2
   抽出extracted with ethyl acetate
3. 3
   乾燥The organic layer was dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).

出典