反応 #11727

反応方程式

chloroacetyl chloride

(2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine

triethylamine

→

title compound

収率 84.9%

2-Chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

収率 84.9%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他The resulting reaction mixture
2. 2
   ろ過The reaction was then filtered through a pad of celite
3. 3
   洗浄washed with dichloromethane
4. 4
   濃縮the resulting filtrate was concentrated

実験手順

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (2.5 g, 11.2 mmol) in dry dichloromethane (11 mL) at 0° C. was added triethylamine (1.57 mL, 11.2 mmol) followed by chloroacetyl chloride (0.86 mL, 11.2 mmol). The resulting reaction mixture was stirred for 30 minutes. The reaction was then filtered through a pad of celite, washed with dichloromethane and the resulting filtrate was concentrated. Chromatography on silica gel gave the title compound (2.84 g).

出典