反応 #11721

反応方程式

chloroacetyl chloride

(3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine

triethylamine

→

title compound

2-Chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   温度to warm to ambient temperature
2. 2
   洗浄washed with 10% citric acid
3. 3
   その他The organic layer was separated
4. 4
   乾燥dried over magnesium sulfate
5. 5
   ろ過filtered
6. 6
   濃縮concentrated in vacuo

実験手順

To a solution of (3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine (3 g, 14.4 mmol) in dichloromethane (40 mL) was added triethylamine (2.0 mL, 14.4 mmol). The reaction was cooled to 0° C. and chloroacetyl chloride was added (1.1 mL, 14.4 mmol). The reaction was allowed to warm to ambient temperature and stirred for 2 hours. The reaction is diluted with dichloromethane and washed with 10% citric acid. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (3.9 g).

出典