反応 #11720

反応方程式

(2R)-2-methyl-piperizine

4-fluorobenzyl chloride

sodium hydrogen carbonate

→

title compound

収率 53.3%

(3R)-1-(4-Fluoro-benzyl)-3-methyl-piperazine

収率 53.3%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The reaction was refluxed overnight
2. 2
   温度cooled
3. 3
   濃縮concentrated
4. 4
   workup.ADDITIONThe remaining residue was diluted with dichloromethane
5. 5
   洗浄washed with water
6. 6
   その他The organic layer was separated
7. 7
   濃縮concentrated
8. 8
   その他to give a clear oil

実験手順

To a solution of (2R)-2-methyl-piperizine (4.5 g, 45 mmol) in ethanol (80 mL) was added 4-fluorobenzyl chloride (5.38 mL, 45.0 mmol) and sodium hydrogen carbonate (11.3 g, 135 mmol). The reaction was refluxed overnight, cooled and concentrated. The remaining residue was diluted with dichloromethane and washed with water. The organic layer was separated and concentrated to give a clear oil. Chromatography on silica gel gave the title compound (5.0 g).

出典