反応 #1172

反応方程式

4-Hydroxypiperidine

Et3N

benzyl chloroformate

CHCl3 MeOH

→

N-Cbz-piperidine

収率 59.2%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   workup.ADDITIONwas added

実験手順

4-Hydroxypiperidine (10.8 g, 107 mmol) and Et3N (17 mL, 123 mmol) in 80 mL of CH2Cl2 was cooled in an ice bath whereupon benzyl chloroformate (16.3 mL, 114 mmol) was added. After stirring 1.5 h at R.T. the mixture was subjected to standard work-up conditions to give 13.9 g (55%) of N-Cbz-piperidine after chromatography (CHCl3 /MeOH; 10:1). [1H]-NMR(CDCl3) consistent with structure.

出典