反応 #1171

反応方程式

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

収率 35.0%

溶媒

EtOAc

DMSO

反応条件

後処理

1. 1
   洗浄washed with 1N aq. HCl, 5N aq. NaOH
2. 2
   乾燥dried over MgSO4
3. 3
   濃縮concentrated

実験手順

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

出典