反応 #11709

反応方程式

hydrochloric acid

sodium hydroxide

4-chloro-2-methoxy-phenol

chloroacetic acid

→

title compound

収率 120.0%

(4-Chloro-2-methoxy-phenoxy)-acetic acid

収率 120.0%

溶媒

water

反応条件

後処理

1. 1
   温度to cool to ambient temperature
2. 2
   抽出extracted with diethyl ether
3. 3
   乾燥The organic layer was dried over magnesium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo

実験手順

To a solution of sodium hydroxide (6.6 g, 160 mmol) in water (45 mL) was added 4-chloro-2-methoxy-phenol (2.0 mL, 16 mmol) and chloroacetic acid (7.7 g, 81 mmol). The resulting mixture was heated to 95° C. and stirred for three hours. The reaction was allowed to cool to ambient temperature and slowly acidified with concentrated hydrochloric acid (10 mL) until the mixture became a solution and then extracted with diethyl ether. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo to give the title compound (4.16 g).

出典