反応 #1169

反応方程式

sulfuryl chloride

benzyl phenyl ether

→

4-benzyloxybenzenesulfonyl chloride

溶媒

DMF

反応条件

後処理

1. 1
   温度cooled
2. 2
   抽出extracted with brine and methylene chloride
3. 3
   乾燥dried over MgSO4

実験手順

A 1.12 portion of anhydrous DMF is cooled to 0° C. and treated dropwise with 2.06 g of sulfuryl chloride. The resulting suspension is stirred for 30 min., then treated with 1.50 g of benzyl phenyl ether. The mixture is heated at 90° C. for 3 h, then cooled, extracted with brine and methylene chloride, and dried over MgSO4. Chormotography on silica gel (i-PrOH/hexanes) yields 4-benzyloxybenzenesulfonyl chloride.

出典