反応 #1168898

反応方程式

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

methyl isocyanate

→

desired product

収率 86.0%

5-[2-(methylcarbamoylamino)ethylthio]imidazo[1,2-a]pyridine

収率 86.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGthe mixture was stirred under ice-
3. 3
   温度cooling for 1 hour
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off
5. 5
   その他the residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5)

実験手順

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.93 g, 10 moles) in methylene chloride (30 ml) was added methyl isocyanate (0.59 ml, 10 moles) under ice-cooling with stirring and the mixture was stirred under ice-cooling for 1 hour. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5) to obtain 2.15 g of the desired product (86.0%, pale yellow crystals).

出典