反応 #1168006

反応方程式

methyl 3-iodobenzoate

toluene

→

title compound

収率 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

収率 29.0%

溶媒

4-iodotoluene

反応条件

後処理

1. 1
   温度The reaction mixture was cooled to room temperature, to which
2. 2
   ろ過Insoluble materials were filtered off
3. 3
   濃縮the filtrate was concentrated to dryness
4. 4
   その他The residue was purified by column chromatography on silica gel

実験手順

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

出典