反応 #1167

反応方程式

lithium aluminum hydride

cis-2-benzyl-7-methoxy-1,3,3a,9b-tetrahydrobenzopyrano[3,4-c]pyrrol-4-one

→

expected product

cis-1-Benzyl-3-hydroxymethyl-4-(2-hydroxy-4-methoxyphenyl)pyrrolidine

溶媒

THF

反応条件

後処理

1. 1
   その他described in Preparation G, at +5° C
2. 2
   温度The reaction medium is maintained at +10° C. for one hour
3. 3
   ろ過is filtered on Celite
4. 4
   その他The organic phase is dried
5. 5
   その他after evaporation

実験手順

To 230 mmol of lithium aluminum hydride in 800 ml of THF, under a nitrogen atmosphere, are added 180 mmol of cis-2-benzyl-7-methoxy-1,3,3a,9b-tetrahydrobenzopyrano[3,4-c]pyrrol-4-one, described in Preparation G, at +5° C. The reaction medium is maintained at +10° C. for one hour before being hydrolyzed, and is filtered on Celite. The organic phase is dried and, after evaporation, gives the expected product.

出典