反応 #1166473

反応方程式

2-(2-hydroxyethyl)-3-methylthiazole

triethylamine

acryloyl chloride

→

dark brown liquid

収率 82.0%

2-(Acryloyloxyethyl)-3-methylthiazole

収率 82.0%

溶媒

chloroform

反応条件

後処理

1. 1
   その他A one liter, three necked flask was equipped with overhead stirrer
2. 2
   抽出The reaction mixture was extracted with NaCl(aq.), NH4OH(10%), NaCl(aq.)
3. 3
   乾燥dried over MgSO4
4. 4
   その他The chloroform was evaporated with a rotoevaporator

実験手順

A one liter, three necked flask was equipped with overhead stirrer, nitrogen atmosphere and an addition funnel. The flask was charged with 100 g of 2-(2-hydroxyethyl)-3-methylthiazole (0.70 mol.), 71 g of triethylamine (0.70 mol.), 500 g of chloroform and 3 g of phenothiazine. Next, 63 g of acryloyl chloride (0.70 mol.) was slowly added to the reaction over 1.5 hour via the addition funnel. The reaction was stirred for 2 hours at room temperature. The reaction mixture was extracted with NaCl(aq.), NH4OH(10%), NaCl(aq.) and dried over MgSO4. The chloroform was evaporated with a rotoevaporator to yield 113 g (82%) of a dark brown liquid. The compound was confirmed by IR and 13C NMR.

出典