反応 #1166472

反応方程式

2-(methylamino)ethanol

furoyl chloride

→

N-(2-hydroxyethyl)-N-methylfuranamide

収率 57.6%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他A one liter, three necked flask was equipped with overhead stirrer
2. 2
   温度The reaction flask was cooled with an ice bath
3. 3
   洗浄The dichloromethane was washed with NaCl(aq.)
4. 4
   抽出Next, the NaCl(aq.) layer was extracted with dichloromethane
5. 5
   乾燥dried over MgSO4
6. 6
   その他The dichloromethane was removed with a rotoevaporator

実験手順

A one liter, three necked flask was equipped with overhead stirrer, nitrogen atmosphere and an addition funnel. The flask was charged with 115 g of 2-(methylamino)ethanol (1.53 mol.) and 500 ml of dichloromethane. The reaction flask was cooled with an ice bath. Next, 100 g of furoyl chloride (0.77 mol.) was slowly added via the addition funnel over 2.5 hours. The dichloromethane was washed with NaCl(aq.). Next, the NaCl(aq.) layer was extracted with dichloromethane and the two dichloromethane layers were combined and dried over MgSO4. The dichloromethane was removed with a rotoevaporator to yield 75 g (44%) of N-(2-hydroxyethyl)-N-methylfuranamide.

出典