反応 #1166466

ord-68f1690fe708447ab5f8deb7618ddc24

反応方程式

CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
hydromorphone HCl
→
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5
Hydromorphone

反応物

—
polyethylene glycol
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
hydromorphone HCl
—
hydroxypropyl methylcellulose
—
D&C Red No. 30 aluminum lake
—
hydroxypropyl cellulose

試薬

[O-2].[O-2].[Ti+4]
titanium dioxide

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.ADDITIONadding Opadry Y-5-1442
  2. 2
    workup.ADDITIONmixing for about 1 hour
  3. 3
    その他to obtain a 20% w/w suspension

実験手順

Drug Loading. Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry Y-5-1442, light pink (a product commercially available from Colorcon, West Point, Pa., which contains hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol and D&C Red No. 30 aluminum lake) and mixing for about 1 hour to obtain a 20% w/w suspension. This suspension was then sprayed onto Nu-Pareil 18/20 mesh beads using a Wurster insert.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05580578uspto-grants-1996_12