反応 #1166463

反応方程式

3-methoxy-4-benzyloxy-7-acetoxy-2H-1-benzopyran -2-one

sodium methoxide

→

title compound

収率 81.1%

3-methoxy-7-hydroxy-4-benzyloxy-2H-1-benzopyran-2-one

収率 81.1%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONThen 2.31 g of Amberlyst-15 (Trademark: Organo corp.) was added
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hour
3. 3
   濃縮the filtrate was concentrated under reduced pressure
4. 4
   その他The precipitate was obtained during concentration
5. 5
   ろ過filtered

実験手順

To a mixture of 3.64 g of 3-methoxy-4-benzyloxy-7-acetoxy-2H-1-benzopyran -2-one (10.7 mmol) in 50 ml of methanol was added 0.58 g of sodium methoxide (10.7 mmol) and the mixture was stirred at room temperature for 1 hour. Then 2.31 g of Amberlyst-15 (Trademark: Organo corp.) was added, and the mixture was stirred at room temperature for 1 hour. Amberlyst-15 was filterd off, the filtrate was concentrated under reduced pressure. The precipitate was obtained during concentration and filtered to give 2.59 g of the title compound. (yield=77%)

出典