反応 #1166460

反応方程式

hydrochloric acid

triethylamine

trans-4-n-propylcyclohexanecarbonyl chloride

water

→

ethyl trans-4-n-propylcyclohexylcarboxylate

溶媒

ethanol

反応条件

後処理

1. 1
   抽出extracted with isopropyl ether
2. 2
   洗浄The organic layer was repeatedly washed with water until the aqueous layer
3. 3
   乾燥by drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography

実験手順

A small amount of triethylamine was added to 10 g (53.6 mmol) of trans-4-n-propylcyclohexanecarbonyl chloride dissolved in 30 ml of ethanol, followed by 10 hours of stirring at room temperature. The reaction mixture was poured into 100 ml of iced water, acidified with 6N-hydrochloric acid and extracted with isopropyl ether. The organic layer was repeatedly washed with water until the aqueous layer became neutral, followed by drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography to obtain 9.9 g of ethyl trans-4-n-propylcyclohexylcarboxylate.

出典