反応 #1166458

反応方程式

hydrochloric acid

p-toluenesulfonic acid chloride

5-methoxyhexanol

water

→

5-methoxyhexyl-p-toluenesulfonate

溶媒

pyridine

pyridine

反応条件

後処理

1. 1
   抽出was extracted with isopropyl ether
2. 2
   洗浄The organic layer was washed with water
3. 3
   乾燥dried with anhydrous magnesium sulfate

実験手順

A solution of 1.83 g (9.6 mmol) of p-toluenesulfonic acid chloride in 5 ml of pyridine was added dropwise to a solution of 1.06 g (8.0 mmol) of 5-methoxyhexanol in 5 ml of pyridine below 5° C. in an iced water bath. After stirring for 6 hours at room temperature, the reaction mixture was injected into 100 ml of cold water and, after being acidified with 6N-hydrochloric acid, was extracted with isopropyl ether. The organic layer was washed with water and dried with anhydrous magnesium sulfate, followed by distilling-off of the solvent to obtain 5-methoxyhexyl-p-toluenesulfonate.

出典