反応 #1166

反応方程式

sodium chloride

isopropyl alcohol

lithium aluminum hydride

methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate

→

expected product

trans-1-Benzyl-3-hydroxymethyl-4-(2-methoxyphenyl)pyrrolidine

溶媒

THF

tetrahydrofuran

反応条件

後処理

1. 1
   その他described in Preparation A)
2. 2
   workup.STIRRINGThe mixture is stirred slowly at room temperature
3. 3
   ろ過After filtration and evaporation of the solvents

実験手順

To 560 mmol of lithium aluminum hydride in 800 ml of tetrahydrofuran (THF), under a nitrogen atmosphere and at 5° C., are added 225 mmol of methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate (described in Preparation A) dissolved in 500 ml of THF. After stirring for 1 hour at 5° C., 139 ml of isopropyl alcohol are added slowly to the above mixture, followed by 85.2 ml of saturated sodium chloride solution. The mixture is stirred slowly at room temperature. After filtration and evaporation of the solvents, the expected product is obtained.

出典