反応 #1161

反応方程式

acetic acid

KMnO4

4-(methylthio)acetophenone

sodium sulfite

→

4-(methylsulfonyl)acetophenone

溶媒

water

water

反応条件

後処理

1. 1
   その他to return to room temperature
2. 2
   workup.WAITThis is left
3. 3
   その他The solid obtained
4. 4
   ろ過is filtered off
5. 5
   洗浄washed copiously with water
6. 6
   その他recrystallized from 95% ethanol

実験手順

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

出典