反応 #11561

反応方程式

Methyl iodide

1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea

→

titled compound

収率 96.0%

4-[3-[3-[2-(1-Adamantyl)ethyl]-3-pentylureido]propyl]-1-methylpyridinium iodide

収率 96.0%

溶媒

acetone

反応条件

後処理

1. 1
   その他The solvent was evaporated under reduced pressure from the reaction mixture
2. 2
   ろ過the precipitated crystals were filtered off with ethyl acetate

実験手順

Methyl iodide (90 μl, 1.5 mmol) was added to a solution of 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-1) (0.30 g, 0.73 mmol) in acetone (1.5 ml) at room temperature, and the mixture was stirred overnight. The solvent was evaporated under reduced pressure from the reaction mixture, and the precipitated crystals were filtered off with ethyl acetate to give 389 mg (96%) of the titled compound.

出典