反応 #1154300

反応方程式

methyl (S)-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzoate

NaOH

→

(S)-3-{[2-(4,5-diphenyl-oxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzoic acid

溶媒

ethanol

tetrahydrofuran

反応条件

後処理

1. 1
   その他the solvent was removed
2. 2
   その他The residue was partitioned between ethyl acetate
3. 3
   洗浄the organic layer was washed with brine
4. 4
   その他The dried solvent was evaporated in vacuo
5. 5
   洗浄the obtained solid was washed with a mixture hexane and ether

実験手順

To a solution of methyl (S)-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzoate (0.3 g) in a mixture of ethanol (8 ml) and tetrahydrofuran (5 ml) was added 1N-NaOH solution (3.5 ml). After being stirred for 24 hours at the same temperature, the solvent was removed. The residue was partitioned between ethyl acetate and lN-HCl and the organic layer was washed with brine. The dried solvent was evaporated in vacuo and the obtained solid was washed with a mixture hexane and ether to afford (S)-3-{[2-(4,5-diphenyl-oxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzoic acid(O.28 g).

出典