反応 #1154299

反応方程式

(1R,2S)-1-(4,5-diphenyloxazol-2-yl)-1-hydroxy-2-(3-methoxybenzyl)cyclohexane

p-toluene-sulfonic acid

→

(S)-2-(4,5-diphenyloxazol-2-yl)-1-(3-methoxybenzyl)-2-cyclohexene

収率 59.6%

溶媒

toluene

反応条件

後処理

1. 1
   温度under reflux
2. 2
   洗浄The solution was washed with water, sat. NaHCO3 and brine
3. 3
   乾燥dried over MgSO4
4. 4
   その他evaporated in vacuo
5. 5
   その他The residue was purified by chromatography on silica gel

実験手順

A mixture of (1R,2S)-1-(4,5-diphenyloxazol-2-yl)-1-hydroxy-2-(3-methoxybenzyl)cyclohexane (28 g) and p-toluene-sulfonic acid (2.5 g) in toluene (300 ml) was stirred for 4 hours under reflux. The solution was washed with water, sat. NaHCO3 and brine, dried over MgSO4 and evaporated in vacuo. The residue was purified by chromatography on silica gel to afford (S)-2-(4,5-diphenyloxazol-2-yl)-1-(3-methoxybenzyl)-2-cyclohexene (16 g).

出典