反応 #11523

反応方程式

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

反応条件

後処理

1. 1
   温度After cooling
2. 2
   抽出extracted twice with ethyl acetate
3. 3
   洗浄The combined solvent phase was washed twice with brine
4. 4
   乾燥dried (magnesium sulphate)
5. 5
   その他evaporated

実験手順

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

出典