反応 #11469

ord-d63943723ec344abb2ab368b9531d738

反応方程式

O=C(Cl)[C@@H]1C[C@H]1c1ccccc1
trans-2-phenyl-1-cyclopropanecarbonyl chloride
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
Cc1nc(N)c2nc(C)n(CCCNC(=O)[C@@H]3C[C@H]3c3ccccc3)c2c1C
desired product
Cc1nc(N)c2nc(C)n(CCCNC(=O)[C@@H]3C[C@H]3c3ccccc3)c2c1C
(1R*,2R*)-N-{3-[4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl]propyl}-2-phenylcyclopropanecarboxamide

反応物

O=C(Cl)[C@@H]1C[C@H]1c1ccccc1
trans-2-phenyl-1-cyclopropanecarbonyl chloride
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Using the method of Examples 78–92, trans-2-phenyl-1-cyclopropanecarbonyl chloride was reacted with 1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 378.2298.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07098221B2uspto-grants-2006_08