反応 #1144443

反応方程式

4-Pentylphenylacetylene

4-acetoxyphenyl iodide

toluene

→

4-(4′-Pentylphenyl)ethynyl phenol

溶媒

diisopropylamine

反応条件

後処理

1. 1
   その他evaporated to dryness on a rotary evaporator
2. 2
   workup.DISSOLUTIONThe residue was redissolved in aqueous potassium hydroxide ethanolic solution
3. 3
   workup.STIRRINGstirred at 70° C. overnight
4. 4
   その他The mixture was evaporated to dryness
5. 5
   その他partitioned between ethyl acetate and water
6. 6
   その他the organic phase was removed
7. 7
   その他dried
8. 8
   その他evaporated
9. 9
   その他The residue was purified by flash column chromatography
10. 10
    workup.WAITA pink coloured solid was left
11. 11
    その他after evaporation of the appropriate fractions
12. 12
    その他1H-NMR and IR spectroscopy gave the expected signals

実験手順

4-Pentylphenylacetylene (10.5 g, 61.4 mmol), 4-acetoxyphenyl iodide (16.1 g, 61.4 mmol), a catalytic amount of Pd(PPh3)2Cl2 and a catalytic amount of copper iodide were stirred in diisopropylamine (100 ml) at 70° C. After 5 minutes, a precipitate was seen and the mixture became unstirrable, toluene (100 ml) was added. The mixture was stirred at room temperature for 24 hours and then evaporated to dryness on a rotary evaporator. The residue was redissolved in aqueous potassium hydroxide ethanolic solution and stirred at 70° C. overnight. The mixture was evaporated to dryness, then partitioned between ethyl acetate and water, the organic phase was removed, dried and evaporated. The residue was purified by flash column chromatography using DCM as eluant. A pink coloured solid was left after evaporation of the appropriate fractions. Yield=10.4 g, 64%. 1H-NMR and IR spectroscopy gave the expected signals.

出典