反応 #1144435

反応方程式

5-ethyluracil

potassium carbonate

→

1-butyl-5-ethyluracil

収率 69.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure
2. 2
   濃縮the organic layer was concentrated under reduced pressure
3. 3
   洗浄eluted with 30% ethyl acetate/hexane

実験手順

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

出典