反応 #1142049

反応方程式

water

3-bromo-2,6-dichloropyridine

sodium methoxide

→

title compound

収率 93.2%

3-bromo-6-chloro-2-methoxypyridine

収率 93.2%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the organic was evaporated
2. 2
   ろ過The resulting suspension was filtered
3. 3
   洗浄the pad was washed with water for several times
4. 4
   その他The pad was dried

実験手順

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

出典