反応 #1142

反応方程式

Sodium borohydride

Carbobenzyloxy-L-proline

5-bromo-3-(2-pyrrolin-1-yl)pyridine

carbobenzyloxy-L-proline

→

5-bromo-3-(2-pyrrolidinyl)pyridine

収率 72.2%

溶媒

DME

methylene chloride

反応条件

後処理

1. 1
   workup.STIRRINGthe resulting mixture was stirred for 2 h at 25° C.
2. 2
   その他affording a colorless solution
3. 3
   その他The solvents were removed in vacuo
4. 4
   workup.DISSOLUTIONthe resuting gum dissolved in methylene chloride (50 mL)
5. 5
   workup.ADDITIONTo this solution was added
6. 6
   workup.STIRRINGthis was stirred at 25° C. for 36 h
7. 7
   その他The solvent was removed in vacuo and 6M HCl (200 mL)
8. 8
   workup.ADDITIONwas added to the residue
9. 9
   抽出The resulting solution was extracted with isopropyl acetate (200 mL)
10. 10
    その他the phases separated
11. 11
    抽出extracted with methylene chloride (3×200 mL)
12. 12
    洗浄The combined methylene chloride extracts were washed with brine (150 mL)
13. 13
    乾燥dried (MgSO4)
14. 14
    濃縮concentrated in vacuo
15. 15
    その他The crude product was chromatographed on silica gel with ethyl acetate

実験手順

Carbobenzyloxy-L-proline (37.4 g, 150 mmol) was dissolved in DME (100 mL) and cooled to 0° C. with stirring. Sodium borohydride (1.89 g, 50 mmol) was added in portions (gas evolution) and the resulting mixture was stirred for 2 h at 25° C. affording a colorless solution. The solvents were removed in vacuo and the resuting gum dissolved in methylene chloride (50 mL). To this solution was added a mixture of 5-bromo-3-(2-pyrrolin-1-yl)pyridine (5.63 g, 25 mmol) and carbobenzyloxy-L-proline (6.23 g, 25 mmol) in methylene chloride (50 mL) and this was stirred at 25° C. for 36 h. The solvent was removed in vacuo and 6M HCl (200 mL) was added to the residue. The resulting solution was extracted with isopropyl acetate (200 mL) and the phases separated. The acidic aqueous phase was basified with solid NaOH to pH 14 and then extracted with methylene chloride (3×200 mL). The combined methylene chloride extracts were washed with brine (150 mL), dried (MgSO4) and concentrated in vacuo. The crude product was chromatographed on silica gel with ethyl acetate, then methanol:ethyl acetate (1:19 to 1:9) as eluants to afford 5-bromo-3-(2-pyrrolidinyl)pyridine (4.1 g, 72%) obtained as a pale yellow oil. LRMS (EI) m/e 227 (C9H11N281 Br--H+) 225 (C9H11N279Br--H+); 1H NMR (DMSO-d6, 300 MHz) δ 8.53 (d, J=2.2 Hz, 1H), 8.49 (d, J=1.8 Hz, 1H), 7.91 (t, J=2.0 Hz, 1H), 4.17 (t, J=7.7 Hz, 1H), 3.18 (m, 1H), 3.06 (m, 1H), 2.00 (m, 1H), 2.07 (s, 1H), 2.00-1.77 (m, 2H), 1.63 (m, 1H).

出典