反応 #11393

反応方程式

1-cyclopropyl-6,7,8-trifluoro-5-methyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

3-aminomethyl-4-hydroxy-piperidine

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titled product

収率 45.9%

1-Cyclopropyl-6,8-difluoro-5-methyl-1,4-dihydro-7-(3′-aminomethyl-4′-hydroxy-piperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

収率 45.9%

反応条件

実験手順

The condensation of 1-cyclopropyl-6,7,8-trifluoro-5-methyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-aminomethyl-4-hydroxy-piperidine was carried out in a similar manner as described in example 1 gave the titled product. Yield 45.9%, m.p 270–75° C., C20H23F2N3O4, m/z 408 (M+1).

出典