反応 #11381

反応方程式

potassium carbonate

2-chloro-3-nitropyridine

cyclohexylamine

→

N-Cyclohexyl-3-nitro-2-pyridineamine

溶媒

DMF

反応条件

後処理

1. 1
   抽出The solution is then extracted with 200 ml of ether
2. 2
   洗浄the organic phase is washed three times with water
3. 3
   乾燥After drying over magnesium sulphate
4. 4
   その他the ether is evaporated off

実験手順

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

出典