反応 #1137992

反応方程式

7-(2,2-dimethyl-propionyloxy)-3-methyl-4-phenyl-isothiazolo[4,5-c]pyridine-6-carboxylic acid butyl ester

N-bromosuccinimide

→

title compound

収率 85.7%

3-Bromomethyl-7-(2,2-dimethyl-propionyloxy)-4-phenyl-isothiazolo[4,5-c]pyridine-6-carboxylic acid butyl ester

収率 85.7%

溶媒

CCl4

反応条件

後処理

1. 1
   温度The reaction mixture was refluxed for 18 h
2. 2
   ろ過was filtered
3. 3
   濃縮The filtrate was concentrated in vacuo
4. 4
   その他purified by flash chromatography on silica gel
5. 5
   洗浄Eluting with 0-20% EtOAc/CH2Cl2

実験手順

To a solution of 7-(2,2-dimethyl-propionyloxy)-3-methyl-4-phenyl-isothiazolo[4,5-c]pyridine-6-carboxylic acid butyl ester (392 mg) in CCl4 (1.8 mL) was added N-bromosuccinimide (172 mg) and benzoyl peroxide (11.1 mg). The reaction mixture was refluxed for 18 h. After cooling to r.t. the mixture was filtered. The filtrate was concentrated in vacuo and purified by flash chromatography on silica gel. Eluting with 0-20% EtOAc/CH2Cl2 gave the title compound (398 mg) as a yellow oil: MS (m/z) 505.1 (M+1), 507.1 (M+1).

出典