反応 #1136

反応方程式

pyridine

fumaric acid

amine

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine

→

5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

収率 70.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他After 30 minutes the solvent was removed in vacuo

実験手順

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.

出典