反応 #1135839

反応方程式

N-cyclopropyl-2-nitroaniline

ammonium formate

→

N1-cyclopropylbenzene-1,2-diamine

収率 97.4%

溶媒

methanol

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux under a nitrogen atmosphere overnight
3. 3
   ろ過filtered
4. 4
   濃縮The filtrate was concentrated
5. 5
   その他purified by biotage column chromatography

実験手順

To a solution of N-cyclopropyl-2-nitroaniline (365 mg, 2.05 mmol) and ammonium formate (516 mg, 8.2 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give N1-cyclopropylbenzene-1,2-diamine (296 mg)

出典