反応 #1135836

反応方程式

8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(6-phenyl-1H-benzo[d]imidazol-2-yl)heptanoate

溶媒

toluene

反応条件

後処理

1. 1
   濃縮concentrated
2. 2
   その他The residue was purified by biotage column chromatography

実験手順

To a solution of 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (120 mg, 0.34 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(6-phenyl-1H-benzo[d]imidazol-2-yl)heptanoate (99 mg)

出典