反応 #1135835

反応方程式

methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate

ammonium formate

→

methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate

収率 85.0%

溶媒

methanol

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux under a nitrogen atmosphere overnight
3. 3
   ろ過filtered
4. 4
   濃縮The filtrate was concentrated
5. 5
   その他purified by biotage column chromatography

実験手順

To a solution of methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate (270 mg, 0.70 mmol) and ammonium formate (177 mg, 2.8 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (211 mg)

出典