反応 #1135833

反応方程式

4-bromo-2-nitroaniline

phenylboronic acid

cesium carbonate

→

4-nitrobiphenyl-3-amine

収率 96.6%

溶媒

ethyleneglycol dimethyl ether

反応条件

後処理

1. 1
   ろ過The mixture was filtered through a celite pad
2. 2
   濃縮The filtrate was concentrated
3. 3
   その他purified by biotage column chromatography

実験手順

To a mixture of 4-bromo-2-nitroaniline (217 mg, 1.0 mmol), phenylboronic acid (122 mg, 1.0 mmol), tetrakis-(triphenylphosphine)palladium (55 mg, 0.05 mmol) and cesium carbonate (650 mg, 2.0 mmol) was added 3 mL of ethyleneglycol dimethyl ether (DME). The reaction was heated to 80° C. and stirred under nitrogen atmosphere overnight. The mixture was filtered through a celite pad. The filtrate was concentrated and purified by biotage column chromatography to give 4-nitrobiphenyl-3-amine (207 mg)

出典