反応 #1135831

反応方程式

methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate

収率 84.3%

溶媒

toluene

反応条件

後処理

1. 1
   濃縮concentrated
2. 2
   その他The residue was purified by biotage column chromatography

実験手順

To a solution of methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate (140 mg, 0.395 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate (113 mg)

出典