反応 #1135828

反応方程式

Acetic acid 3-(3,4-dimethoxy-phenyl)-8-methyl-4-oxo-chroman-7-yl ester

imidazole

H2O

→

3-(3,4-Dimethoxy-phenyl)-7-hydroxy-8-methyl-chroman-4-one

溶媒

EtOH

反応条件

後処理

1. 1
   workup.ADDITIONbefore pouring
2. 2
   ろ過A fine white precipitate was filtered off

実験手順

Acetic acid 3-(3,4-dimethoxy-phenyl)-8-methyl-4-oxo-chroman-7-yl ester (1.1 g, 3.2 mmol) and imidazole (3.2 g, 47 mmol) were refluxed in EtOH (100 ml). The reaction was complete after 90 minutes and allowed to cool to room temperature before pouring into stirred H2O (800 ml). A fine white precipitate was filtered off and 1H NMR in d-CDCl3 indicated the solid was 3-(3,4-Dimethoxy-phenyl)-7-hydroxy-8-methyl-chroman-4-one in >95% purity (0.31 g, 30%).

出典