反応 #1135820

反応方程式

methyl laurate

dimethylaminobutanol

→

3-dimethylaminopropyl laurate

収率 67.0%

反応条件

後処理

1. 1
   その他A syringe was inserted
2. 2
   その他through the cap
3. 3
   その他Nitrogen was bubbled at a rate sufficient
4. 4
   workup.ADDITIONto mix the contents
5. 5
   その他set to 65° C
6. 6
   温度to cool
7. 7
   その他The Novozym 435 was removed by filtration
8. 8
   その他to afford the product as a pale, yellow oil (9.2 g; 67% yield)
9. 9
   その他without further purification

実験手順

To a 50-mL conical bottom plastic vial was added methyl laurate (38.5 mmol), dimethylaminobutanol (46.2 mmol, 1.2 eq), and Novozym 435 (400 mg). A syringe was inserted through the cap and two additional holes were punched for gas to exit. Nitrogen was bubbled at a rate sufficient to mix the contents. The vial was placed in a heating block set to 65° C. The reaction was monitored by GC/MS to observe the disappearance of starting material. The reaction was complete after approximately 24 hours. The reaction mixture was allowed to cool. The Novozym 435 was removed by filtration to afford the product as a pale, yellow oil (9.2 g; 67% yield) without further purification.

出典