反応 #1135805

反応方程式

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他To the reaction mixtures
2. 2
   抽出the mixtures were extracted with ethyl acetate
3. 3
   洗浄The organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   乾燥were dried over anhydrous sodium sulfate
5. 5
   濃縮The resulting mixtures were concentrated under reduced pressure

実験手順

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

出典