反応 #1135800

反応方程式

1-bromo-2-methyl-3-aminobenzene

triphosgene

→

1-bromo-3-isocyanato-2-methylbenzene

収率 106.3%

溶媒

toluene

反応条件

後処理

1. 1
   温度with heating
2. 2
   温度under reflux for three hours
3. 3
   温度to cool
4. 4
   濃縮were concentrated under reduced pressure

実験手順

A mixture of 1-bromo-2-methyl-3-aminobenzene 25.0 g, triphosgene 60.0 g and toluene 400 mL was stirred with heating under reflux for three hours. The reaction mixtures after standing to cool were concentrated under reduced pressure to give 1-bromo-3-isocyanato-2-methylbenzene 30.3 g.

出典