反応 #1135797

反応方程式

methyl chloroformate

tetrahydrofuran

1-chloro-2-methyl-3-aminobenzene

→

1-chloro-2-methyl-3-methoxycarbonylaminobenzene

溶媒

water

反応条件

後処理

1. 1
   その他To the reaction mixtures
2. 2
   抽出the resulting mixtures were extracted with ethyl acetate
3. 3
   洗浄The organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   乾燥were dried over anhydrous sodium sulfate
5. 5
   濃縮The mixtures were concentrated under reduced pressure

実験手順

Under cooling, to a mixture of methyl chloroformate 30 mL and tetrahydrofuran 50 mL was added dropwise 1-chloro-2-methyl-3-aminobenzene 5.00 g and the mixtures were stirred at 25° C. for a half hour. To the reaction mixtures was added water and the resulting mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The mixtures were concentrated under reduced pressure to give 1-chloro-2-methyl-3-methoxycarbonylaminobenzene 5.80 g.

出典